Statin Muscle Toxicity and Genetic Risk Factors
نویسندگان
چکیده
In the context of statin monotherapy, the frequency of myopathy is ~1/1,000, and the frequency of rhabdomyolysis is ~1/100,000. The frequency increases with dose [7,8]. Clinicians often measure serum CK levels, as parameter of severity, but the correlation between symptoms and CK level is incomplete. Therefore, the clinical interpretation of CK level is complex. Elevations less than three-fold the ULN are typically of little consequences. Conversely, the physician often changes the dose or the therapy when the levels increase 3-fold the ULN.
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